Selective expression of Narp, a secreted neuronal pentraxin, in orexin neurons
نویسندگان
چکیده
منابع مشابه
Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy.
OBJECTIVE To investigate whether neuronal activity-regulated pentraxin (Narp) colocalizes with hypocretin (Hcrt or orexin) in the normal human brain and to determine if Narp staining is lost in the narcoleptic human brain. BACKGROUND Human narcolepsy is characterized by a loss of the peptide hypocretin in the hypothalamus. This loss could result from the degeneration of neurons containing hyp...
متن کاملConcomitant loss of dynorphin, NARP, and orexin in narcolepsy.
BACKGROUND Narcolepsy with cataplexy is associated with a loss of orexin/hypocretin. It is speculated that an autoimmune process kills the orexin-producing neurons, but these cells may survive yet fail to produce orexin. OBJECTIVE To examine whether other markers of the orexin neurons are lost in narcolepsy with cataplexy. METHODS We used immunohistochemistry and in situ hybridization to ex...
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We have identified, by affinity chromatography, a binding protein for the snake venom toxin taipoxin. The sequence of this 47 kDa protein is unique, is characteristic of a secreted protein, and has homology to the acute phase proteins serum amyloid P protein and C-reactive protein of the pentraxin family. We have named this protein neuronal pentraxin (NP), as Northern analysis and in situ hybri...
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Synaptic Clustering of AMPA Receptors by the Extracellular Immediate-Early Gene Product Narp
Narp (neuronal activity-regulated pentraxin) is a secreted immediate-early gene (IEG) regulated by synaptic activity in brain. In this study, we demonstrate that Narp possesses several properties that make it likely to play a key role in excitatory synaptogenesis. Narp is shown to be selectively enriched at excitatory synapses on neurons from both the hippocampus and spinal cord. Overexpression...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2002
ISSN: 0022-3042
DOI: 10.1046/j.1471-4159.2002.01141.x